Development and evaluation of a mechanical chest compression device for standardized rodent cardiopulmonary resuscitation.

ABSTRACT: Small animal models are indispensable in cardiopulmonary resuscitation (CPR) research. High-quality CPR, characterized by consistent chest compression rate, depth, and positioning is crucial for survival. However, achieving standardization in manual high-frequency chest compressions in small animal models remains technically challenging. This study evaluated the reproducibility of manual chest compressions and introduced a novel mechanical chest compression device (MCD) designed to improve consistency in rodent experiments. In an in vitro setup, manual compressions were performed by ten participants at target rates ranging from 100 to 260 bpm, guided by a metronome. Compressions performed on a fluid-filled polymer reservoir were analyzed for the compression rate, variability, and time with

SUBMITTER: Brixius SJ 

PROVIDER: S-EPMC12689703 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature