Association of Preoperative Gut Microbiota Disturbances with Postoperative Infectious Complications in Major Gastrointestinal Cancer Surgery: A Large-Scale Exploratory Study.

ABSTRACT:

Background

Gut microbiota and intestinal environment are crucial in minimizing the risk for postoperative infectious complications of major gastrointestinal cancer surgery. However, comprehensive studies across multiple cancer types with large samples are limited. This study aimed to identify preoperative factors associated with the development of infectious complications after such surgeries.

Methods

This large-scale exploratory study examined 381 patients who underwent surgery for seven types of gastrointestinal cancer. Preoperative fecal samples were analyzed for fecal organic acid concentrations using high-performance liquid chromatography and gut microbiota composition 16S rRNA gene amplicon-sequencing. The relationships between specific gut bacteria, lactic acid concen

SUBMITTER: Sugimoto T 

PROVIDER: S-EPMC12689735 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature