Epidemiological and transcriptome data identify potential key genes involved in inflammatory response for diabetic nephropathy.

ABSTRACT: The neutrophil percentage-to-albumin ratio (NPAR) is a novel inflammatory marker, and diabetic nephropathy (DN) are linked to inflammation. The primary objective of this investigation was to elucidate the functions and underlying mechanisms of inflammatory response in the development of DN. Epidemiological data from the National Health and Nutrition Examination Survey (NHANES) spanning 2009 to 2018 were utilized to systematically investigate the association between NPAR and DN. Furthermore, transcriptomic data from the Gene Expression Omnibus (GEO) were analyzed using bioinformatics approaches to examine potential functional mechanisms, focusing on gene expression and immune cell infiltration. A significant positive association was observed between NPAR and the risk of DN, as indicated by

SUBMITTER: He S 

PROVIDER: S-EPMC12689796 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature