Clinical and neuropsychological features associated with progression in subjective cognitive decline.

ABSTRACT:

Background and objectives

Subjective Cognitive Decline (SCD) is recognized as an early indicator of neurodegeneration, yet factors that predict its progression to mild cognitive impairment (MCI) or dementia remains not fully understood. In this study, we aim to identify clinical and neuropsychological features associated with the progression of SCD.

Methods

450 persons with SCD were included, consisting in 319 non progressors (SCDnp) and 131 progressors (SCDp) to MCI or dementia due to AD. The study was conducted at the Clínica Universidad de Navarra Memory Clinic between 2001 and 2017. We included data on medical interviews and neuropsychological evaluations. Differences between SCDnp and SCDp were assessed and, to evaluate the association between exposure variables and pro

SUBMITTER: Villino-Rodriguez R 

PROVIDER: S-EPMC12689879 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature