Inflammatory markers partially mediate the association between volatile organic compounds exposure and hyperlipidemia: a nationally representative cross-sectional study from NHANES.

ABSTRACT:

Background

While studies have explored associations between volatile organic compounds (VOCs) and metabolic diseases, evidence specifically linking VOCs to hyperlipidemia remains limited. This study aimed to examine the association between urinary VOC metabolites and hyperlipidemia prevalence in U.S. adults.

Methods

Leveraging data from the 2011-2018 National Health and Nutrition Examination Survey (NHANES), this study employed weighted logistic regression, restricted cubic spline (RCS) models, weighted quantile sum (WQS) regression, quantile-based g-computation (qgcomp), and Bayesian kernel machine regression (BKMR) to evaluate associations of individual and mixed VOC exposures with hyperlipidemia. All models were adjusted for covariates including sex, age, race/ethnicity,

SUBMITTER: Nie Y 

PROVIDER: S-EPMC12689905 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature