Dynamic functional connectivity of the amygdala-hippocampal complex is associated with cognitive impairment in adolescents with Internet gaming disorder.

ABSTRACT:

Background

The amygdala-hippocampal complex (AHC) plays a central role in the neural mechanisms underlying Internet Gaming Disorder (IGD), particularly in emotional regulation, memory processing, and reward-related functions. However, the dynamic interactions between the AHC and large-scale brain networks, and their relationship with cognitive performance in IGD, remain poorly understood.

Methods

A total of 123 adolescents (66 with IGD and 57 healthy controls) underwent resting-state functional magnetic resonance imaging (fMRI). Temporal fluctuations in AHC connectivity were assessed using dynamic functional network connectivity (dFNC) analysis. Correlation and mediation analyses were conducted to investigate the relationship between aberrant AHC-related dFNC and cognitive f

SUBMITTER: Zhao T 

PROVIDER: S-EPMC12689908 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature