Electroacupuncture Prevents Against AD-Like Phenotypes in APP/PS1 Mice: Investigation of the Mechanisms From Cerebral Microangiopathy.

ABSTRACT:

Background

Electroacupuncture (EA) has been widely used in Alzheimer's disease (AD) treatment. However, its underlying mechanisms remain poorly elucidated.

Purpose

This study aimed to investigate the effects of EA on AD-like phenotypes and explore the mechanisms.

Methods

We first evaluated AD-like behaviors and cerebral blood flow (CBF) changes in APP_swe/PS1dE9 (APP/PS1) mice at different ages. Subsequently, the therapeutic effects of EA at acupoints Baihui (GV20), Guanyuan (CV4), and Zusanli (ST36), as well as sunitinib, a PDGFRβ-specific inhibitor, on AD-like phenotypes in APP/PS1 mice were investigated. CBF was monitored by laser speckle imaging, and hippocampal synaptic ultrastructure and microvascular morphology were examined by transmission electron m

SUBMITTER: Yang C 

PROVIDER: S-EPMC12689941 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature