Balanced multi-electrolyte solution versus normal saline for fluid therapy in aneurysmal subarachnoid hemorrhage: an influence on fluid and electrolytes balance and outcome.

ABSTRACT:

Introduction

Isotonic crystalloids are commonly used for maintaining fluid balance and cerebral perfusion pressure in critical care patients with aneurysmal subarachnoid hemorrhage (aSAH). However, the relatively high concentration of chloride in normal saline (NS) might lead to hyperchloremia or acute kidney injury, comparing with multi-electrolyte solutions (BMES). The aim of the study is to compare the incidence of hyperchloremia in aSAH patients and provide feasibility and safety research for further study.

Methods

This is a pilot study of a single center, randomized, controlled trail. Patients were enrolled randomly to receive BMES or NS for 3 days of ICU stay.

Results

Overall, 87 patients were randomized to receive BMES or NS, 60 patients (30 in each group) were

SUBMITTER: Duan YQ 

PROVIDER: S-EPMC12689972 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature