Estrogen associations with human pregnancy related increases in cytochrome P450 3A activity.

ABSTRACT:

Introduction

Increased CYP3A-mediated drug clearance during pregnancy can lead to subtherapeutic dosing of CYP3A substrates. Pregnancy-related hormones (PRHs) increase CYP3A4 expression and activity in cultured human hepatocytes. However, the factors in maternal circulation that regulate pregnancy-mediated changes in CYP3A activity remain unclear.

Methods

This study investigated the association between maternal plasma concentrations of key steroidal PRHs and biomarkers of CYP3A activity in human pregnancy, and the impact of individual PRHs on CYP3A4 expression in primary human hepatocytes. Concentrations of estrone (E1), estradiol (E2), progesterone (P4), and cortisol (CRT), and 4β-hydroxycholesterol (4β-OH-CHO) and the 4β-OH-CHO:CHO ratio (endogenous bi

SUBMITTER: Fashe MM 

PROVIDER: S-EPMC12689976 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature