Clinical Utility of Serum Neurofilament Light Chain in Peripheral Neuropathy.

ABSTRACT:

Introductions/aims

The clinical utility of serum neurofilament light chain (sNfL) in the evaluation and management of peripheral neuropathy (PN) remains poorly defined. This study aimed to evaluate the utility of sNfL for diagnosing PN, assessing disease activity, and monitoring treatment response using a commercially available assay.

Methods

This was a retrospective cohort study at the University of Pennsylvania between June 2024 and March 2025. Patients with, or at risk for, PN who underwent sNfL testing were included. Demographics, PN etiology, clinical findings, and sNfL levels were analyzed.

Results

One hundred and twenty-eight patients were included: 41 with chronic inflammatory demyelinating polyneuropathy (CIDP), 36 with transthyretin amyloidosis (ATTR), 13 wi

SUBMITTER: Karam C 

PROVIDER: S-EPMC12690012 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature