The association between Sjogren's disease and sex hormones: A case-control and Mendelian randomization study.

ABSTRACT:

Objective

To identify the association between sex hormones and Sjogren's disease.

Methods

A case-control study investigating the relationship between sex hormones and Sjogren's disease was conducted at Nanjing Drum Tower Hospital from January 2018 to January 2024. Two-sample Mendelian randomization was then performed to identify the causal association by using the public genome-wide association study data from the UK Biobank and the FinnGen consortium.

Results

In the case-control study, a total of 93 cases diagnosed with Sjogren's disease were compared to 90 Sjogren's disease-like non-Sjogren's disease controls from a population of naturally postmenopausal women. An association was observed between E2 (aOR = 0.984; 95% CI: 0.971-0.997; p = 0.018), hypo-estradio

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12690054 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature