Blastulation and ploidy prediction using morphology assessment in 33,999 day-3 embryos.

ABSTRACT: Although contemporary practice in in vitro fertilization (IVF) favors embryo transfer at blastocyst stage, several centres worldwide employ cleavage-stage Day-3 embryo transfers. The advantage of cultures extended to Day-5 and beyond, is to ensure that the embryo to be transferred will not arrest between Day-3 and Day-5, and that it provides additional morphological quality markers that can be used for selection. To bridge that gap for centres that practice Day-3 transfers, we intended to model the association between Day-3 morphology and blastulation/ploidy tested with modern sequencing technologies, and to develop a validated predictive model for these outcomes. We conducted a retrospective cohort study including 33,999 Day-3 embryos from 5,702 cycles between March 2017 and December 2021

SUBMITTER: Elkhatib I 

PROVIDER: S-EPMC12690125 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature