Perfusion and Structural Impairment in Minor Stroke and Transient Ischemic Attack With Intracranial Atherosclerotic Stenosis: Associations With Cognitive Decline.

ABSTRACT:

Aims

To investigate the characteristics of hypoperfusion and structural impairment in patients with transient ischemic attack (TIA) or minor stroke (MS) with intracranial atherosclerotic stenosis (ICAS) and evaluate its impact on cognitive decline.

Methods

Cognitive function in 47 patients and 33 health controls (HC) was assessed using the Montreal Cognitive Assessment (MoCA) tool. Arterial spin labeling with two distinct postlabeling delays and 3D T1 imaging was conducted to assess cerebral blood flow (CBF), morphometric features, and asymmetry index (AI).

Results

Compared with HC, both the left and right involved patients showed reduced scores for total MoCA score. Comparisons of CBF with HC revealed that significant ischemic areas in patients were primarily localiz

SUBMITTER: Shang M 

PROVIDER: S-EPMC12690161 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature