Magnetic resonance imaging determination of tissue sodium across the CKD spectrum-associations and implications for health.

ABSTRACT:

Background

Increased tissue sodium (Na⁺) concentration is associated with adverse clinical outcomes in people with chronic kidney disease (CKD) including hypertension, inflammation and increased cardiovascular disease (CVD). 23-Sodium magnetic resonance imaging (²³Na-MRI) can non-invasively quantify tissue Na⁺ concentration. However, in the CKD population, few studies have evaluated relationships between ²³Na-MRI-derived tissue Na⁺ concentrations and measures of Na⁺ metabolism, surrogate markers of CVD and other CKD-related health complications.

Methods

We conducted a cross-sectional cohort study, involving 51 participants with CKD (28 with non-dialysis CKD, 23 on dialysis), to explore relationships between

SUBMITTER: Martin K 

PROVIDER: S-EPMC12690200 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature