Novel integrated approach modeling proanthocyanidins and bacteriophages to combat multidrug <i>Salmonella</i> Typhimurium in challenged broilers.

ABSTRACT: The emergence of multidrug bacterial isolates, including Salmonella (S.) Typhimurium, which primarily spreads to humans through chicken products, is correlated with a rising prevalence of antimicrobial therapy failure. Thus, we performed a comprehensive analysis of the combined impact of Salmonella bacteriophage (BP) and grape seed oligomeric pro-anthocyanidins (GSOPs) on growth performance, immune functions, antioxidant capacity, cecal microbiota, gut integrity, and S. Typhimurium resistance in challenged broilers. A total of 250 Ross-308 male broiler chicks were offered either a control diet or a diet supplemented with Salmonella BP alone at concentrations of 10⁹ PFU/0.1 ml, GSOPs alone at a level of 400 mg/kg diet, and a combination of both

SUBMITTER: Al-Khalaifah HS 

PROVIDER: S-EPMC12690214 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature