Cost-Effectiveness of Fracture Prevention in Postmenopausal Women With Early Breast Cancer in China.

ABSTRACT:

Background

Aromatase inhibitors (AIs) significantly increase the risk of osteoporosis and related fractures in postmenopausal women with hormone receptor (HR)-positive early breast cancer (EBC), posing a substantial clinical and economic burden. Effective fracture prevention strategies are critical, especially in resource-constrained settings such as China.

Methods

A Markov microsimulation model was developed to evaluate the cost-effectiveness of fracture prevention strategies for 60-year-old postmenopausal women with HR-positive EBC treated with AIs in China. Six strategies were compared: (a) no intervention, (b) one-time bone mineral density (BMD) screening followed by anti-osteoporotic medication for patients with osteoporosis or osteopenia, (c) annual BMD screening follo

SUBMITTER: Liu JY 

PROVIDER: S-EPMC12690219 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature