Temporal Trends in Medical and Surgical Management of Ulcerative Colitis in England: 2003-2020.

ABSTRACT:

Background

The medical management of ulcerative colitis (UC) is evolving. However, colectomy may be required in severe or refractory cases.

Aim

To provide contemporary evidence on medication usage and surgery for UC.

Methods

An incident cohort of patients newly diagnosed with UC from 2003 to 2020 was identified using computerised health records. The cumulative incidence of colectomy and medication use was calculated using Kaplan-Meier methods and compared across 3 time periods. We calculated 90-day post-operative mortality using life tables. Cox regression was used to model the risks of surgery and mortality, adjusting for confounders.

Results

33,464 subjects had an incident diagnosis of UC. 5- year cumulative incidence of elective colectomy reduced from 2.97%

SUBMITTER: Couch J 

PROVIDER: S-EPMC12690229 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature