Impact of Frailty on the Prognosis of Patients With Liver Cirrhosis Undergoing Insertion of a TIPS.

ABSTRACT:

Background and aims

Frailty is associated with a poorer prognosis of patients awaiting liver transplantation. Data on the impact of frailty on prognosis after transjugular intrahepatic portosystemic shunt (TIPS)-insertion in patients with cirrhosis and the influence of TIPS on longitudinal changes in frailty are lacking.

Methods

We retrospectively analysed data of 123 prospectively recruited patients with cirrhosis in Mainz and Hannover prior to elective TIPS insertion and monitored them for death/liver transplantation or post-TIPS overt hepatic encephalopathy (OHE). Patients underwent testing with the Liver Frailty Index (LFI) prior to TIPS insertion as well as 1, 3 and 6 months after TIPS placement.

Results

Median LFI prior to TIPS insertion was 4.32 (interquartile

SUBMITTER: Kabelitz MA 

PROVIDER: S-EPMC12690237 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature