IL-10- and IL-13-Biased T Cell Responses to SARS-CoV-2 Vaccination in Diabetes.

ABSTRACT: Type 1 and type 2 diabetes are associated with increased severity and mortality from respiratory virus infections. Vaccination in the general population significantly reduces the risk of severe respiratory viral infection and triggers a strong, polyfunctional, and lasting T cell response in healthy individuals. However, vaccine effectiveness in people with type 1 diabetes is unclear. Here, we studied the magnitude and functional characteristics of vaccine-specific CD4⁺ and CD8⁺ T cell responses to vaccination in people with type 1 and type 2 diabetes and compared them to those of people living without diabetes, using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine as a model. We found defects in both CD4⁺ and CD8⁺ T cell

SUBMITTER: Jones EM 

PROVIDER: S-EPMC12690275 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature