Activating NRF2^E79Q mutation alters the differentiation of human non-small cell lung cancer.

ABSTRACT: The NRF2 signaling pathway promotes tumor initiation, progression and resistance to chemotherapy, radiation therapy and immune checkpoint inhibitors. The mechanisms underlying the biology of NRF2-active tumors are varied and include altered cellular metabolism, a reductive shift in redox state, and immunosuppression. Here we determined the molecular and phenotypic impact of NRF2 activation on two human non-small cell lung cancer (NSCLC) cell models. Inducible expression of NRF2^E79Q, a common activating NRF2 mutation, in H358 lung adenocarcinoma (LUAD) cells altered cellular morphology and increased xenograft tumor growth in mice but not in 2D cell culture. In contrast, NRF2^E79Q expression in H596 lung adeno-squamous cell carcinoma altered cellular morphology, increase

SUBMITTER: Hamad SH 

PROVIDER: S-EPMC12690292 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature