Fully individualized models for cross-sectional and longitudinal network-based tau spread.

ABSTRACT: Heterogeneity in regional tau burden limits evaluation of disease progression using one-size-fits-all approaches. Prior work using tau positron emission tomography (PET) has highlighted the important role of connectivity to epicenters of tau pathology in explaining this heterogeneity. However, previous studies using population-based epicenters or connectomes fall short of a fully individualized approach to predicting regional tau burden. We use diffusion MRI-derived structural connectomes to assess the prediction of regional tau burden using distance along individual structural connectomes from individualized epicenters of tau pathology both cross-sectionally and longitudinally. Fully individualized models of connectivity and epicenters outperformed models using either population-based con

SUBMITTER: Brown CA 

PROVIDER: S-EPMC12690294 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature