The influence of intercalated disk nanostructure on local ionic currents and cardiac conduction.

ABSTRACT: The intercalated disk (ID) is a structurally heterogeneous junctional complex essential for synchronized cardiac conduction and contraction. Previous computational models have investigated the influence of ID structure on cardiac conduction. However, most have relied on oversimplified geometries and uniformly distributed ion channels, limiting their ability to capture nanoscale heterogeneity. In this study, we expand our previous finite element mesh framework to produce a more physiologically realistic representation of the ID, incorporating spatially heterogeneous gap junctions and multiple ion and ionic current dynamics. We systematically quantify the impact of key structural and electrophysiological features on conduction by generating a comprehensive library of 384 ID mesh configuratio

SUBMITTER: Sui R 

PROVIDER: S-EPMC12690334 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature