The role of PSMA PET/CT in staging patients with intermediate-risk prostate cancer.

ABSTRACT:

Objective

To synthesise data evaluating the diagnostic utility of prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) in intermediate-risk prostate cancer (PCa), as its role in intermediate-risk PCa remains uncertain.

Methods

A systematic search was conducted for studies evaluating PSMA PET/CT in primary staging of newly diagnosed European Association of Urology (EAU)/National Comprehensive Cancer Network (NCCN) intermediate-risk, or Gleason Score 7 (International Society of Urological Pathology [ISUP] Grade Group [GG] 2-3) PCa. The primary outcome was overall positive scans (lymph nodes or distant metastases). We also secondarily analysed diagnostic accuracy measuring sensitivity, specificity, positive predictive value, and ne

SUBMITTER: Bonaddio J 

PROVIDER: S-EPMC12690344 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature