TTF-1 expression is associated with survival in patients with non-squamous non-small cell lung cancer treated with immune checkpoint inhibitor therapy.

ABSTRACT: Thyroid transcription factor-1 (TTF-1) expression has been associated with the prognosis of patients with non-small cell lung cancer treated with immune checkpoint inhibitor (ICI) therapy; however, it has also been suggested that there is no such link. The present study analyzed the association of TTF-1 expression, evaluated using a cocktail antibody (TTF-1/napsin A; clone, SPT24/TMU-Ad02), with survival after the initiation of ICI therapy in patients with EGFR/ALK wild-type non-squamous non-small cell lung cancer receiving first-line treatment with ICI monotherapy or chemoimmunotherapy. A total of 49 patients were enrolled to the present study. Multivariate analysis using the Cox proportional hazard model showed that TTF-1 expression was associated with progression-free survival (PFS) aft

SUBMITTER: Murayama N 

PROVIDER: S-EPMC12690345 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature