Assessment of new prognostic risk models for recurrence in patients with clinical stage I seminoma.

ABSTRACT:

Objectives

To evaluate two new prognostic risk models aimed at improving clinical decision-making in patients with clinical stage (cS) I seminomatous testicular germ cell tumours (GCTs), 5%-30% of whom experience recurrence during surveillance after orchiectomy and may benefit from adjuvant therapy.

Methods

In this exploratory study, patients with unilateral cS I seminoma, normalised serum tumour markers after orchiectomy, no adjuvant therapy and at least 12 months of follow-up were included. Cox regression analysis was applied to evaluate the prognostic factors proposed by the Danish Testicular Cancer Database (DaTeCa) and the European Association of Urology (EAU), and recurrence probabilities were estimated using the Kaplan-Meier method.

Results

Among 139 patients,

SUBMITTER: Strauch A 

PROVIDER: S-EPMC12690351 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature