Risk and Outcomes of Secondary Cancer Among Lung Cancer Survivors After Definitive Treatment.

ABSTRACT:

Importance

Second primary cancers are an important cause of morbidity, mortality, and resource use among lung cancer survivors, yet their risk relative to recurrence and their determinants have been incompletely defined.

Objectives

To quantify the competing risks of recurrence, intrathoracic new cancer (locoregional or distant recurrences confined to the thorax and/or second primary lung cancers), and non-lung secondary cancers (NLSCs) after curative-intent local therapy for non-small cell lung cancer (NSCLC) and to identify clinical factors associated with NLSC.

Design, setting, and participants

This cohort study included consecutive stage I to III NSCLC survivors treated with definitive local therapy and evaluated in a dedicated survivorship clinic at a single high-

SUBMITTER: McMillan MT 

PROVIDER: S-EPMC12690424 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature