Inotrope selection in mixed cardiogenic shock with sepsis: a comparative analysis between milrinone and dobutamine.

ABSTRACT:

Rationale

Despite increasing recognition of mixed cardiogenic shock-particularly in patients with concomitant sepsis-there remains limited guidance on optimal inotropic selection, and the comparative effectiveness of different inotropes in this population is unclear.

Objective

To examine the association between inotrope selection and in-hospital outcomes, including all-cause mortality, among patients with cardiogenic shock and sepsis.

Methods

Using the PINC AI enhanced-claims database (2016-2022), we identified patients with cardiogenic shock and sepsis using International Classification of Diseases, Tenth Revision codes (ICD-10) that were present on hospital admission and a pharmacy charge code for dobutamine or milrinone within 2 days of hospitalization. The primary

SUBMITTER: Li B 

PROVIDER: S-EPMC12690451 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature