Exploring the mechanism of action of Jinqiancao granules against liver cirrhosis based on the liver-gut axis.

ABSTRACT:

Background

Current treatments for cirrhosis-a progressive disease marked by fibrosis and inflammation-are limited and non-specific. Jinqiancao granules (JQC), a traditional Chinese medicine used for hepatobiliary diseases, could provide a promising new therapeutic approach.

Purpose

The objective of this study is to explore the therapeutic effects and potential molecular mechanisms of JQC on CCl₄-induced liver cirrhosis in mice, and to analyze its effects on the liver-gut axis, including liver pathology, the intestinal barrier, and gut microbiota.

Methods

To investigate the therapeutic effects of JQC and its impact on the liver-gut axis, a mouse model of liver cirrhosis was established by intraperitoneal injection of carbon tetrachloride (CCl₄). T

SUBMITTER: Cheng FE 

PROVIDER: S-EPMC12690457 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature