Sensors Manufacturing on a 3D-Printed Transwell-Based Hybrid Organ-on-a-Chip for Non-Invasive Real-Time Biological Barrier Resistance Monitoring.

ABSTRACT: Biological barriers in our body are dedicated to maintaining systemic homeostasis by enabling selective transport, the dysregulation of which plays a pathogenic role in several diseases. Transendothelial/epithelial electrical resistance (TEER) analysis is conventionally used to assess the barrier permeability. Engineering TEER setups within advanced in vitro models has become essential for acquiring real-time information on barrier integrity inside organ-on-a-chip (OOC) devices. However, current approaches often involve multiple assembly steps, require external access to the culture chamber, rely on cumbersome systems, or provide highly localized measurements that do not represent the entire surface of the tissue under examination. Specifically, in Transwell-based OOC systems, continuous a

SUBMITTER: Perottoni S 

PROVIDER: S-EPMC12690515 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature