3D Peri-Implant Epi-Mucosa-on-a-Chip Reveals Alterations in Epithelial Barrier Function Mediated by Host-Bacteria-Biomaterial Interactions.

ABSTRACT: Peri-implantitis is characterized by disruption of the epithelial barrier at the implant-mucosa interface, driven by complex interactions between mechanical, microbial, and material factors. Histological and immunohistochemical analysis of human peri-implant and periodontal tissues revealed significant epithelial abnormalities specific to peri-implantitis, which indicated compromised barrier integrity. Specifically, peri-implant tissues had increased intercellular edema, inflammatory infiltration, and marked loss of junctional proteins E-cadherin and ZO-1. To further investigate these findings in a controlled environment, we developed a novel 3D Peri-implant Epi-mucosa-on-a-chip model incorporating clinically relevant titanium surfaces, hydrostatic pressure, and bacterial challenge

SUBMITTER: Surrency S 

PROVIDER: S-EPMC12690518 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature