Noncoding and coding mechanisms of aging-related heart failure with preserved ejection fraction associated with thyroid dysfunction.

ABSTRACT: Heart failure with preserved ejection fraction (HFpEF) is a lethal, heterogeneous, geriatric syndrome. Long noncoding RNAs (lncRNAs) constitute the majority of the functional mammalian transcriptome and are key regulators in complex pathophysiological processes. However, the roles of lncRNAs in aging HFpEF associated with thyroid hormone (TH) dysfunction are unclear. We used the well-established ZSF1 rat model to investigate early and severe age-related HFpEF in 5-, 13- or 20-months-old (mo) animals. Both serum THs significantly decreased in HFpEF in a temporal manner. Echocardiograms showed preserved cardiac function. Gravimetric and histologic analyses showed significant cardiac hypertrophy in HFpEF. Microarrays and RT-qPCR revealed that three lncRNAs were significantly increased predomi

SUBMITTER: Chakraborty S 

PROVIDER: S-EPMC12690541 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature