Playing with Structural Parameters in the Design of Ruthenium(II)-<i>p</i>-Cymene Complexes as Potential Antibacterial Agents.

ABSTRACT: A series of ruthenium(II) arene complexes of the general formula [(η⁶-pCymene)Ru(L)Cl]PF₆ (hereafter RACs) have been designed, synthesized, and characterized with a view to their possible use as antimicrobial agents. We specifically report on five structurally related RAC complexes, i.e., Ru-pCy1-5, incorporating bidentate polypyridyl ligands of different nature (L1 = benzo[i]dipyrido[3,2-a: 2',3'-c]phenazine, L2 = 4,7-diphenyl-1,10-phenanthroline, L3 = 2,2'-biquinoline, L4 = 2,2'-bipyridine-4,4'-diylbis(morpholinomethanone), L5 = (2,2'-bipyridine-4,4'-diylbis(morpholinomethylene)). The complexes Ru-pCy1-5, which showed substantial inertness when dissolved in aqueous media, were investigated by ESI-MS for their ability

SUBMITTER: Giacomazzo GE 

PROVIDER: S-EPMC12690573 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature