Combined Metal-Metal and Metal-Ligand Cooperativity in Dicopper-Catalyzed Azide-Alkyne Cycloaddition Reactions.

ABSTRACT: The mechanism of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction has been under investigation for over two decades. While catalytically relevant dicopper intermediates have been proposed and a few suspected intermediates have been isolated, the mechanism remains poorly understood. In this work, we describe the synthesis and characterization of neutral dicopper complexes bearing the proton-responsive dinucleating ^iPr PNNP "expanded pincer" ligand, which are demonstrated to be relevant intermediates in the CuAAC reaction. The acetylide complex [Cu₂( ^iPr PNNP*)-(μ-CC-p-F-C₆H₄)] (2) reacts with 1-azido-4-fluorobenzene at ambient temperature to form the dicopper com

SUBMITTER: van Beek CB 

PROVIDER: S-EPMC12690585 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature