Transcriptomic analysis of <i>Streptococcus pneumoniae</i> serotype 1 reveals serotype-specific gene regulation.

ABSTRACT: Streptococcus pneumoniae (Sp) is an opportunistic pathogen that colonizes the mucosal surfaces of the human upper respiratory tract. While transcriptomic studies of Sp have become more common, most have focused on laboratory-adapted strains such as D39 or TIGR4. These strains, though widely used in research, may not fully capture the biology of clinical isolates, particularly the hypervirulent serotype 1 (S1). S1 is clinically significant due to its association with invasive disease, epidemic outbreaks and a distinct global distribution, particularly in regions with a high pneumococcal disease burden. Unlike many other serotypes, S1 is frequently linked to hypervirulence and a propensity for rapid spread, making it a high-priority target for understanding the molecular

SUBMITTER: Pongchaikul P 

PROVIDER: S-EPMC12690605 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature