Anatomical distribution of disease in pN1 prostate cancer with BCR post-RP: A PSMA-PET/CT-based analysis.

ABSTRACT:

Objectives

To explore the distribution of metastatic disease in pN1 patients with biochemical recurrence (BCR) assessed by Prostate-Specific Membrane Antigen-Positron-Emission/Computed Tomography (PSMA-PET/CT).

Patients and methods

This multicentre, retrospective cohort study included 130 pN1 PCa patients with BCR (PSA ≥ 0.2 ng/ml) post-RP with ePLND (2015-2022). All were preoperatively staged as molecular imaging (mi)N0M0 and underwent restaging PSMA-PET/CT at BCR. Clinical and imaging data were analysed using Mann-Whitney U, chi-square tests and Cox regression.

Results

Median time to BCR was 9 months (IQR 3-18). Biochemical persistence (BCP) (PSA ≥ 0.1 ng/ml at first follow-up) occurred in 66/130 (51%). At restaging PSMA-PET/CT, median PSA was 0.33 ng/ml (IQR 0.24-0

SUBMITTER: Zuur LG 

PROVIDER: S-EPMC12690614 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature