Small intestinal SMARCA4-deficient undifferentiated carcinoma with intussusception: A case report.

ABSTRACT: Switch/sucrose non-fermentable (SWI/SNF) related matrix associated actin-dependent regulator of chromatin sub-family A member 4-deficient undifferentiated carcinoma (SMARCA4-DUC) of the small intestine is a rare and highly aggressive subtype of gastrointestinal malignancy. The present study reported the case of SMARCA4-DUC in a patient who presented with intestinal intussusception and multi-organ metastasis to the lungs, liver, spleen and skin, which led to rapid progression and death in 43 days. The present case highlighted the unique histological and molecular features of SMARCA4-DUC, characterized by the absence of SMARCA4 expression and undifferentiated cellular morphology. The present case report aimed to describe the clinical presentation, imaging findings, pathological features and

SUBMITTER: Cai X 

PROVIDER: S-EPMC12690633 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature