Association of maternal pre-existing atherosclerotic cardiovascular disease and neonatal and long-term offspring outcomes: a nationwide mother-child paired cohort.

ABSTRACT:

Study question

Is maternal pre-existing atherosclerotic cardiovascular disease (ASCVD) associated with neonatal and long-term offspring outcomes?

Summary answer

Maternal pre-existing ASCVD is independently associated with consistent increases in neonatal and early childhood adverse outcomes.

What is known already

Maternal cardiovascular health may influence offspring development through intrauterine and early-life mechanisms. However, the impact of maternal pre-existing ASCVD on neonatal and long-term offspring's neurodevelopmental outcomes remains poorly understood.

Study design size duration

We conducted a nationwide cohort study linking maternal and child health data from the Korean National Health Insurance Service between 2005 and 2019.

Participants/mat

SUBMITTER: Kang D 

PROVIDER: S-EPMC12690663 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature