Using a single penetrating interfascicular electrode to improve spatial selectivity of an extraneural polymeric cuff array.

ABSTRACT:

Background

Damage to the peripheral nervous system severely disrupts motor control, sensory perception, and organ function, often resulting in long-term disability. To restore such impairments, peripheral nerve interfaces (PNIs) aim to achieve precise stimulation selectivity, yet current approaches face several limitations. Most PNIs rely on metal-based electrodes, which introduce a mechanical mismatch with soft neural tissue and are limited by low charge-injection capacity. The device design of these PNIs also suffers from a fundamental trade-off: highly invasive approaches enable high selectivity but provoke strong foreign-body responses, while less invasive designs minimize tissue damage but fail to provide sufficient selectivity. Although current-steering strategies have been e

SUBMITTER: Ben M'Rad I 

PROVIDER: S-EPMC12690793 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature