Early peripheral blood gene expression predicts 90-day outcomes following subarachnoid hemorrhage.

ABSTRACT:

Background

Previous clinical, radiological and machine learning studies have predicted 90-day outcomes following subarachnoid hemorrhage (SAH). The present study was designed to determine whether early changes in mRNA expression of immune, clotting and other genes expressed in peripheral blood can predict patient outcomes at 90 days after SAH and possibly provide insights into the molecular factors that promote good versus poor outcomes.

Methods

Peripheral blood was drawn after SAH and from vascular risk factor controls (VRFC) and RNAseq performed to measure mRNA expression. A mixed effects regression model identified potential predictors and machine learning algorithms derived the best predictors of 90-day SAH outcome as measured by modified Rankin Score (mRS) for a derivat

SUBMITTER: Knepp B 

PROVIDER: S-EPMC12690849 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature