Unique Sertoli cell adaptations support enhanced spermatogenesis in chickens.

ABSTRACT:

Background

The cellular basis of testicular development and spermatogenesis for the extreme sperm density in chickens (100-fold higher than mammals) remains poorly defined. A comprehensive understanding of the molecular characteristics driving poultry testicular development is crucial for explaining this enhanced spermatogenic capacity.

Results

Here, we first established a single-cell transcriptome profile of chicken testes from hatching to maturity, identifying the dynamic transcriptional characteristics of germ cell fate transition and exploring the developmental characteristics of Sertoli cells and Leydig cells. Multi-species comparisons revealed a higher proportion of germ cells and the unique adaptations of Sertoli cells in chicken testes. Most importantly, our results

SUBMITTER: Xu G 

PROVIDER: S-EPMC12690856 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature