Adipose tissue-derived microRNAs as epigenetic modulators of type 2 diabetes.

ABSTRACT:

Background

White adipose tissue (WAT) dysfunction including an aberrant expression of miRNAs is strongly associated with the risk of developing type 2 diabetes (T2D), with limited evidence linking early changes in the WAT-derived miRNAs and T2D. The present study aims to identify early miRNome changes prognostic for T2D in mice and humans.

Methods

Gonadal (g) WAT of diabetes-resistant and diabetes-prone mice were subjected to multi-omics analyses (transcriptome, miRNome, methylome, proteome). Metabolic phenotypes linked with T2D were correlated with adipose tissue miRNA expression and DNA methylation from 14 monozygotic twin pairs discordant for T2D. Plasma miRNA levels from females at high risk of developing T2D (TÜF study) were included.

Results

Adipose tissue of th

SUBMITTER: Sehgal R 

PROVIDER: S-EPMC12690927 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature