Acute kidney injury predicts mortality, sarcopenia and postoperative morbidity in myxofibrosarcoma patients undergoing surgical resection.

ABSTRACT:

Background

Myxofibrosarcoma (MFS) is a rare, aggressive soft tissue sarcoma primarily affecting older adults. Despite curative-intent surgery and multimodal therapy, outcomes remain variable. Acute kidney injury (AKI) and sarcopenia are known complications in oncologic care, but their incidence and impact in MFS patients remain unclear.

Objective

To assess the incidence and consequences of AKI in adult MFS patients undergoing curative-intent surgery, and its association with survival, CT-based sarcopenia progression, and postoperative morbidity.

Methods

In this retrospective single-center study, 49 adults with high-grade, N0M0 MFS who underwent curative-intent resection with or without multimodal therapy were included. AKI was defined as a ≥ 0.3 mg/dL increase in seru

SUBMITTER: Kylies J 

PROVIDER: S-EPMC12690947 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature