Ribosomal protein RPL7A modulates lung adenocarcinoma progression via circRANBP17-UPF1-mediated SIRT6 degradation.

ABSTRACT:

Background

Lung cancer, primarily lung adenocarcinoma (LUAD), is the leading cause of cancer-related deaths worldwide. Despite extensive research, the mechanisms behind LUAD progression remain inadequately understood, underscoring the need for new biomarkers and therapeutic targets. Ribosomal proteins, traditionally associated with protein synthesis, are gaining recognition for their roles in tumorigenesis, though many functions remain unexplored.

Methods

This study utilized single-cell transcriptomic data and bioinformatics analyses to identify potential LUAD biomarkers. Selected biomarkers were validated using quantitative PCR (qPCR) and immunofluorescence on clinical samples. Functional roles were assessed through in vivo and in vitro assays, including migration, invasion

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12690969 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature