Multiple Myeloma in Young Adults-Insights From a Tertiary Care Cancer Centre in India.

ABSTRACT:

Background

Multiple myeloma (MM) is primarily a disease of the elderly; data on young patients are limited.

Aim

To evaluate the clinical characteristics and outcomes of MM patients aged ≤ 40 years.

Methods

We retrospectively analyzed newly diagnosed MM patients aged ≤ 40 years between 2013 and 2021.

Results

Of 1980 patients screened, 110 (5.5%) were ≤ 40 years (median age 36). Hypercalcemia, renal dysfunction, anemia, and bone lesions (CRAB) were seen in 11.9%, 17.3%, 42.7%, and 92.6% of patients, respectively. More than one-third had International Staging System (ISS) Stage III, 20.8% had HR cytogenetics and 21.6% had light chain disease (LCD). Macrofocal multiple myeloma (MFMM) seen in 31% of patients. Bortezomib-cyclophosphamide-dexamethasone (VCd) and borte

SUBMITTER: John G 

PROVIDER: S-EPMC12690978 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature