ST32da, a Novel <i>Salvia miltiorrhiza</i>-Derived ATF3 Inducer, Alleviates Obesity-Related Diabetic Nephropathy in Mouse Models.

ABSTRACT: It is necessary to find novel therapeutic strategies for obesity-related diabetic nephropathy (DN) that target both metabolic dysfunction and renal inflammation. ST32da derived from Salvia miltiorrhiza (a well-recognized Traditional Chinese Medicine) induces activating transcription factor 3 (ATF3), a negative regulator of inflammation and metabolic stress. However, the effects of ST32da on obesity-related DN remain underexplored. We investigated the therapeutic potential of ST32da, a synthetic ATF3 inducer derived from Salvia miltiorrhiza, in mitigating obesity-related DN in both in vivo and in vitro models. The Nephroseq database analysis was performed to explore the relationship between Atf3 expression and DN progression. ST32da was administered to db/db knockout and DBA m

SUBMITTER: Chen HH 

PROVIDER: S-EPMC12691026 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature