Clinical Chemistry Reference Intervals for Health Assessment in Wild Adult Harbour Seals.

ABSTRACT: Reference intervals for clinical chemistry blood parameters are valuable for both individual diagnostics for animals in managed or veterinary care, and for evaluating wild population health. However, for marine mammals obtaining sufficient data from suitable groups or populations is logistically difficult. Here, we have assembled a large dataset of clinical chemistry results from free-living adult UK harbour seals (Phoca vitulina), analysed in the same commercial laboratory. We applied an open-source algorithm (available as the R package refineR, R version 4.5.2, refineR version 2.0.0) to produce robust reference intervals from these Real-World Data. This novel approach resulted in the generation of 95% reference intervals with 90% confidence bounds for 18 key chemistr

SUBMITTER: Hall AJ 

PROVIDER: S-EPMC12691109 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature