The Role of Plasmacytoid Dendritic Cells in the Immune Contexture of <i>TP53</i>-Mutated High-Grade Serous Ovarian Cancer.

ABSTRACT: Background/Objectives: This study aimed to characterize dendritic cell (DC) heterogeneity, immune associations, and prognostic relevance across three TP53-mutated tumor entities-high-grade serous ovarian cancer (HGSOC), triple-negative breast cancer, and endometrial cancer-focusing on plasmacytoid DCs (pDCs) in HGSOC. Methods: RNA-sequencing and clinical data of 603 patients from The Cancer Genome Atlas were analyzed. DC subset abundance was assessed for cDC progenitor, conventional DC type 1 (cDC1), conventional DC type 2 (cDC2), plasmacytoid DC (pDC), and mature DC by marker gene signatures. Differences in DC scores across tumors were analyzed using Kruskal-Wallis. Survival analyses were performed using Kaplan-Meier and Cox regression. Spearman's correlation was used

SUBMITTER: Steger K 

PROVIDER: S-EPMC12691120 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature