Neuroserpin: A Potential Neuroprotective Agent in Mild Neonatal Hypoxic-Ischaemic Encephalopathy.

ABSTRACT: Neonatal hypoxic-ischaemic encephalopathy (HIE) remains a leading cause of infant morbidity and mortality worldwide, with therapeutic hypothermia being the only clinically approved treatment. This study investigates the cortical expression pattern of neuroserpin during postnatal brain development and evaluates its neuroprotective potential in hypoxia-ischaemia (HI)-induced brain damage using a modified Rice-Vannucci model. Experiments were conducted in both male and female neuroserpin knockout (KO) mice and through administration of exogenous neuroserpin into the brain. Between postnatal day 4 to 14 (P4-P14), neuroserpin-immunoreactive cell density peaked at P8-P10 in cortical layers 5 and 6b, with a gradual increase in layers 2/3 and minimal changes in layers 4 and 6a. Despite comparable

SUBMITTER: Kawashita E 

PROVIDER: S-EPMC12691123 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature