Buc Maintains Maternal RNA Stability and Embryogenesis in Zebrafish.

ABSTRACT: The maternal-to-zygotic transition (MZT) is a fundamental process in vertebrate embryogenesis, involving the clearance of maternal mRNA and activation of the zygotic genome. Orchestration of maternal mRNA stability ensures early embryogenesis. Recently, some germ plasm (GP) factors have been demonstrated to regulate the stability of maternal mRNA. Bucky ball (Buc) functions as a zebrafish GP organizer. However, it remains unclear whether Buc also protects maternal mRNAs from widespread decay in early embryos. Here, we report that overexpression of buc results in delayed maternal mRNA degradation and a concomitant delay in embryonic development, whereas buc knockout leads to accelerated maternal mRNA degradation and severe developmental defects, suggesting that both gain and l

SUBMITTER: Miao R 

PROVIDER: S-EPMC12691124 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature