Imbalance in MICOS Proteins in Rat Liver Mitochondria in an Induced Hyperthyroidism Model.

ABSTRACT: This study investigated rearrangements in the cristae structure and the possible relationship between these changes and the MICOS levels in the liver mitochondria of rats with experimentally induced hyperthyroidism. In hyperthyroid rats (HRs), the number, area, and perimeter of mitochondria were increased, and organelles of a worm-shaped, branched, highly elongated, or spherical shape appeared. A structural change in the mitochondria of HR liver was detected, consisting of a decrease in the number of cristae relative to the cross-section of the organelle. In some mitochondria, multilamellar bodies were detected. Hyperthyroidism caused an increase in the expression of genes and the level of proteins of the MIC60 subcomplex, with an unchanged level of the MIC10 subcomplex. Moreover, the leve

SUBMITTER: Venediktova N 

PROVIDER: S-EPMC12691126 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature